Pete Alonso belted a walk-off two-run homer in the 10th inning on Thursday for the host New York Mets, who posted a 7-6 win over the St. Louis Cardinals hours after learning Max Scherzer would miss six-to-eight weeks with a left oblique injury.

The Mets took three of four from the Cardinals but lost Scherzer, who exited Wednesday's game in the sixth inning after feeling a "zing" in his left oblique. An MRI administered Thursday revealed a "moderate to high grade" strain. Alonso had three hits and three RBIs, and Jeff McNeil also knocked home three runs.

Colin Holderman (1-0) earned his first big league win despite giving up the go-ahead unearned run in the top of the 10th inning.

The Cardinals rallied from a pair of two-run deficits and tied the game in the ninth inning before going ahead in the 10th on a run-scoring double play by Albert Pujols. Paul Goldschmidt blasted his sixth homer of the season among his three hits and four RBIs, and Juan Yepez also went deep.

Orioles 9, Yankees 6

Anthony Santander hit a three-run home run in the bottom of the ninth to lift Baltimore to a win over visiting New York and end a six-game losing streak.

Santander, who went 3-for-4 with two doubles, three runs scored and a walk, hit the first walk-off home run of his career when he drove a cutter from Yankee reliever Lucas Luetge (1-1) down the left field line with one out.

Santander's 376-foot blast came after Austin Hays reached on an error and Trey Mancini singled to center. Reliever Felix Bautista (1-1) picked up the win for the Orioles, who had seen Jorge Lopez blow a save opportunity in the top of the inning.

Padres 2, Phillies 0

Yu Darvish tossed seven strong innings and Robinson Cano had an RBI single to fuel visiting San Diego to victory over Philadelphia.

Darvish (4-1) allowed six hits, all singles, to go along with five strikeouts and no walks. Taylor Rogers recorded the final four outs to earn his 15th save in 16 opportunities. Manny Machado added two of the 10 hits for the Padres, who shut out the Phillies for the second time in the three-game series.

Rhys Hoskins had two hits for Philadelphia, which was shut out for the fifth time this season. Both teams combined for 18 hits, with all of them being singles. Bryce Harper was held out of the lineup for a fourth straight game after receiving a PRP injection in his right elbow on Sunday.

Reds 4, Guardians 2

Cincinnati scored three runs in the eighth inning for a victory over host Cleveland.

The Reds swept the two-game series and have won eight of their past 12 games after a 3-22 start as the Guardians have lost five of six. Tyler Naquin had a pair of hits and a home run for Cincinnati.

The Reds jumped all over reliever Trevor Stephan (2-1), who was rocked for three runs on three hits in two-thirds of an inning in the eighth. It ruined an outstanding start by right-hander Cal Quantrill, who surrendered one run on five hits in seven innings. He didn't walk a batter and struck out five.

White Sox 7, Royals 4

Luis Robert was 3-for-4 with a home run and four RBIs as Chicago defeated host Kansas City, taking the rare five-game series three games to two.

Robert's homer in the eighth gave the White Sox their largest lead, capping six straight runs for the Sox. The White Sox scored five of their seven runs on hits with an 0-2 or 1-2 count. Bennett Sousa (2-0) earned the win in relief. Liam Hendriks earned his 12th save, saving all three White Sox wins in the series.

Gabe Speier (0-1) took the loss for Kansas City, allowing a run and three hits in just one-third of an inning. The White Sox scored at least five runs for just the ninth time in their 38 games, but they could have had more. They left eight runners on base in the first four innings, a total of 11 in the game.